The old master has a vision in which Athena is decapitated by Hades. At that moment he realizes that the end has come the day when Hades and his 108 Specters return to Earth. In the Sanctuary, Mū finds that several Knights have revived by the power of Hades in exchange for bringing the head of Athena. Among them Death Mask of Cancer and Pisces Aphrodite are the first to fight, along with a mysterious third Knight who is able to destroy the incredible defense of Mū.
Aphrodite and Death Mask see as Seiya's body is gone, but the third Saint doubts Mū killed Pegasus. The Arian is furious with Cancer and Pisces; then makes them disappear with the extinction of the starlight attack.
Castle in Hades, the Spectre Radamanthys of Wyvern meets his love Pandora. And disobeying her, he sends more than 10 Specters to fight at the 12 houses. In Japan, Shun feels he must go to the Sanctuary to fight for Athena, and leaves not before defeating Tatsumi who tried to stop him.
Saga tells Shura and Camus to continue as he will take care of Gemini. Saga recognizes the opponent as his brother, and seeing that he is controlling the armor of Gemini from a distance and launches an attack that reaches the Hall of Patriarch. Milo of Scorpio finds himself with Kanon of Gemini and orders him to leave. After the refusal of the Knight, Milo begins to attack with his Scarlet Needle.
Saga, Shura and Camus find that the interior of the house of Cancer has become a gateway to the world of the dead, but realize it's an illusion.
Dohko and Shion begin to fight, but the Knight of Libra is overpowered because of his age and the youth of Shion granted by Hades. Shiryū arrives only to see his master is defeated and wants to intervene, but can do nothing against the power of Shion.
Mū reachs the remains of the house of Cancer and is immobilized by a large group led by Spectrum Giganto of Cyclops and Papillon Myu. When Ariano was going to be eliminated he is saved by Seiya who reappears but is beaten by Giganto, when they were about to finish it Myu stops his comrades and orders them to follow.
Seiya falls exhausted and waking up meets Shiryū, Hyōga and Shun. Meanwhile, led by Giganto the Spectras arrive at the house of Leo, meeting Aioria. Then 5 Specters are launched against Aioria but he kills them with one hit, others hesitate what to do anything until Raime of Worm says he will eliminate the Knight.
Giganto is furious when he learns that Saga and the others killed three Specters to impersonate them against Shaka, Gemini is not interested and warns him to leave if he doesn’t want to be killed.
Everyone can feel it in the Sanctuary, Shaka of Virgo is dead. In the Garden three Knights are surprised as Shaka is still there, but what he does is write something with blood in the cherry blossoms and finally disappears from this world.
Shion and Dohko are still alive, and the previous Patriarch cries over the deaths of Aldebaran, Death Mask and Aphrodite. While concerned about the fates of Saga, Shura, Camus, Mu, Aiolia and Milo. The power of both Athena and Exclamation is immense and the Bronze Saints are swept back by the power of it.
Shion begins to mourn in front of Athena's blood spilled on the floor, she is able to wake the armor of Athena, which is the true form of the giant statue of the goddess in the Sanctuary, a small stone figurine that becomes an armor.
The Bronze Saints want to fight against Radamanthys, but the Golden Knights stop them telling them that this is their task and send them to assist Saga and the others. Seiya and the others agree and say goodbye to Mū, Milo and Aiolia so they can keep fighting.
Shiryū, Shun and Hyōga meet Dohko at the entrance to the pit where Seiya and Radamanthys fell. Saint of Libra tells them they must now awaken their Eighth Sense in order to enter the world of the dead without getting killed. The 4 raise their cosmos and are thrown into the hole.
Seiya and Shun come to the courthouse and notice how quiet it is. Arriving at the entrance they encounter a soldier who tells them to keep silence, but Seiya ends up sneezing. The soldier gets hysterical and says that if his master "Lune" hears he will be punished. He then tells them that when they are in front of him, tell all their sins.
Seiya and Shun leave the Valley of Air and run in the rain as they encounter an Egyptian building. Suddenly a smell of death reaches them and they discover a three-headed monster that is eating the dead. Seiya and Shun try to sneak away from the monster, but he sees and attacks.
Orpheus plays the strings of his lyre and Pharaoh loses control of his hand and drops the armor of Athena, which Seiya collects. Orpheus and Pharaoh face off in combat of music.
Radamanthys says “it's not time for music”, Pandora tells him to remain silent, and that in no way should they bother telling Hades everything that happens in the world of the dead. While Orpheus plays and the four close their eyes and hear the melody of the lyre, Hades is on his throne behind a curtain, while Orpheus plays his Mortal Serenade.
Hyōga and Shiryū wake after crossing the Fourth Prison, but they do not see Kanon and deduce that they must continue with the mission. So they run down the Fifth Prison in reach him. The Fifth Prison is the place for those who did not have the protective teachings of a God, atheists. The bodies of these people are forever burned in tombs.
Garuda gets up and hits Ikki, and to end it he decides to use his most powerful technique: Galactic Illusion.
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